Immune defense at the ocular surface
نویسندگان
چکیده
منابع مشابه
Cortisol Biosynthesis in the Human Ocular Surface Innate Immune Response
Innate immune responses have a critical role in regulating sight-threatening ocular surface (OcS) inflammation. While glucocorticoids (GCs) are frequently used to limit tissue damage, the role of intracrine GC (cortisol) bioavailability via 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in OcS defense, remains unresolved. We found that primary human corneal epithelial cells (PHCEC), fib...
متن کاملTrafficking of Immune Cells in the Cornea and Ocular Surface
The role of immuno-inflammatory responses in the cornea and ocular surface has continuously been evolving over the past decades and has been becoming the center stage for therapeutic approaches for many diseases. In fact, the relevance of inflammation as a significant component in the pathophysiology of most acute and chronic forms of corneal and ocular surface diseases (e.g., microbial keratit...
متن کاملSialomucin complex at the rat ocular surface: a new model for ocular surface protection.
The ocular surface, which is among the most accessible and vulnerable tissues in mammals, is protected by a complex tear film composed of lipid, aqueous and mucin layers. In spite of its importance, the molecular nature of the mucin contribution remains uncertain. Since membrane mucins have been implicated in the protection of other epithelia, we have analysed rat corneal and conjunctival tissu...
متن کاملGoblet cell loss abrogates ocular surface immune tolerance.
Intestinal epithelial cells condition tolerogenic properties in DCs. Aqueous-deficient dry eye is associated with goblet cell (GC) loss and increased IFN-γ expression in the conjunctiva. We hypothesized that loss of GCs reduces tolerance-inducing properties of antigen presenting cells (APCs) in the conjunctiva and draining nodes. Mice lacking the SAM pointed domain containing ETS transcription ...
متن کاملThe spectrum of antimicrobial peptide expression at the ocular surface.
PURPOSE Antimicrobial peptides are the eukaryotic analogues of antibiotics. In addition to their antimicrobial activity, these peptides can signal to host cells and are therefore intermediaries between the innate and adaptive immune systems. Results in a prior study showed that beta-defensins-1 and -2 are made by ocular surface epithelial cells. In the present study, a survey was made of antimi...
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ژورنال
عنوان ژورنال: Eye
سال: 2003
ISSN: 0950-222X,1476-5454
DOI: 10.1038/sj.eye.6700617